Who’s afraid of Vitamin E?

I feel that there is a problem some people have fully understanding the ingredients listing on their food products.  Recent regulation requiring nutrition information to be displayed prominently and ingredients lists to be accurate combined with truth-in-advertising laws have gone a long way in mitigating fear of foods; yet, a comprehensive ingredients list is a double-edged sword.  Like fire in the hands of a child who does not know how to use it safely can be mean agonizing death; in the hands of a master chef, it can bring a scrumptious zest to lif .

For one thing, yes, there are some additives that are designed to extend the shelf-life–last time you made bread with only flour, water, and yeast, how long did it last (incidentally, check the ingredients in your “enriched flour”; it should list many of what people identify as “chemicals” but really are only the chemical names for common vitamins; such is the case with the pyridoxine and calcium pantothenate highlighted in red in the original post).

Some other “chemicals” are actually chemical names for common baking ingredients. Calcium carbonate, a component of mollusc shells and a common antacid, is simply chalk. All the -glycerides are simply different forms of fatty acid esters. Many times people will see something like “ammonium bicarbonate” and associate it with “ammonia,” which is not technically false because the ammonium ion really is the same functional group, but acting as an ionic compound with bicarbonate, it simply acts, as sodium bicarbonate does, as baking soda.

I do not disagree that unnecessary additives are often included, but without many stabilizers and antioxidants (many of which sound scarier than they really are–for example, our common vitamin E, is more commonly known by its chemical name of tocopherol, and so d-alpha-tocopheryl acetate is simply vitamin E bonded to an acetate (the same ion that makes vinegar acetic aid) moiety. In fact, the IUPAC systematic name for vitamin E would become 2,7,8-trimethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-ol. It might look scary, but how many of us are scared of vitamin E?

People should not substitute ignorance of chemistry or biology for fear.

Arrogance of Science, and Rubiks Cubes

I have found that modern scientists have a certain arrogance that was not as evident in the past–a sense that “science has arrived,” and “we didn’t know better back then, but we got it right, now.” And it is this feeling that science cannot do wrong now, I believe, more than anything else, that is dangerous. The other day, I heard on CBC radio (Canadian Broadcasting Corporation is Canada’s public broadcaster, and might be compared to NPR, but it also comprises three radio streams and does broadcast content from alternative, contemporary, and classical music to talk radio) the other day that some scientists had begun to think that the greenhouse gases were out of control and that a viable solution would be to build an orbiting solar shield to counter global warming. That is precisely the kind of thinking that I find is absolutely irresponsible that happens across the pure, applied, and social sciences. We see it in medicine when a researcher makes the leap from “low blood levels of X result in Y,” to a drug that raises X and causes all sorts of complications with Z, W, and the other due to complex interactions that were difficult to anticipate given the rigid framework of quantitative methods. We see it in economics when we build increasingly accurate econometric models that are great for explaining what is causing economic crises and then try to operate these models in reverse to fix economies.

Some of the most famous and pivotal scientific developments of our time were once developed by Catholic priests and monks. Some of the most compelling mathematical and engineering developments have been made by devout Muslims in the earlier years of Islam. Yet now, the divide between science and religion has never been greater; indeed, the father of modern genetics can be considered a Catholic priest, Gregor Mendel, who studied heritability in pea plants. Having completed my own degree largely in molecular genetics (although I also extensively studied evolutionary and population genetics) before I had converted to Catholicism, people look at me in amazement and wonder how I can responsibly call myself a Catholic, knowing what I do as a scientist. Still more are shocked that I converted from no religion to Catholicism after completing my degree.

Before beginning my MBA in 2000, I was faced during my GMAT exam with a question pertaining to government funding of the arts, as part of my Analytical Writing Assessment. I cannot, of course, go further into detail about the question since I signed an agreement not to disclose test questions, but at the time I still held the belief that arts, such as literature and visual arts, should be maintained as hobbies, while artists supports their own–and society’s–needs through being a regular employed contriburing member of society. I now see the value of government funding of the arts. I now see the value of what could not be achieved without this freedom. I extend the same belief to science. With increasing funding coming from industry–with its associated expectations to do science that satisfies an intermediate- to short-term business goal–it is vital that the government maintain adequate funding–especially to the pure sciences–such that research without directly obvious commercial application or that runs afoul of current industry wisdom will still be carried out. University research must not be allowed to become an extension of a pharmaceutical R&D lab.

It is interesting how I arrived at that belief through inductive reasoning. I have recently become a huge fan of the Rubiks Cube, and subsequently, all of its larger cousins available commercially, ranging from the 2x2x2 Rubiks Cube to the 7x7x7 V-Cube 7. I have made many discoveries in pure inductive reasoning through it. I often found that traditional logic puzzles have a weakness where any critical thinker can “outsmart” the questions by thinking of exceptions and “what ifs.” Indeed, that might be the *responsibility* of a critical thinker. But reduced to coloured cubelets moving around, the Rubiks-type cube puzzles present to me a pure opportunity to study reasoning, much like Chess is to strategy.

I realize that there exist many algorithms to solve the cube, some of which involve no problem-solving or strategic skills whatsoever, and while I do not find much value in using these mindlessly following steps to solve the cubes, I do now encourage all beginning cubers to learn the simplest beginner methods–which reduce solving the basic 3x3x3 cube to six basic steps, recognizing a simple situation, and repeating a series of repeated moves–in order to be able to solve the cube well enough without thinking that the cuber can begin to focus on watching the behaviours of the cubelets. When I begin teaching someone to DJ or play the piano, for example, it is impossible to learn things like phrasing or articulating motifs while still trying to learn the technical skills; thus, beginners to musical instruments must focus on technique before interpretation. Likewise with cubing, a beginner set of algorithsms helps be able to solve the cube and focus entirely on studying the cubelet movements without being distracted by also thinking how to solve the cube.

But once someone is able to solve the cube in under roughly two minutes, I advise abandoning the beginner method for more intuitive ones. My favourite of these, the Jessica Fridrich method, eschews the initial first- and second-layer algorithms for a set of intiutive steps that complete the first two layers simultaneously.

When one progresses to the 4x4x4 cube (and higher order cubes), they will recognize immediately that the most common general solutions for them are to reduce the cube into a 3x3x3 and solve as usual–all centre cubelets are filled in and move as a single centre, and all edge cubelets between corners are paired and move as a single edge piece. There are issues that can arise in a 5×5 that could not exist in a 4×4 (a 5×5 has a 3×3 centre, whereas a 4×4 has only a 2×2 centre–in order to fill in 5×5 centres, it is necessary to fill in a 2×3 on one face, and a 1×3 on a separate face; then displace a 1×3 line of the 2×3, rotate the face, and return the displaced 1×3 in the empty 1×3 slot). This strategy had to be deveoped because the 4×4 only had two 1×2 slots for centres, whereas the 5×5 has three 1×3 slots.

When generalizing, therefore, is the pattern to fill in centres layer-by-layer, or to fill in two separate halves of a centre and join them? That is also not evident yet because the 5×5 does not have enough layers to abstract that information.

Moving onto the 6x6x6 cube (which has a 4×4 centre), it is readily apparent that the way to fill in centres is buiding two separate 2×4 segments and merging them because once a 3×4 block is created, attempts to displace and replace a1×4 block will disrupt the portion of the block between the middle of the cube and the second layer. Moving onto the 7×7, new challenges to the approach that worked so well for the 4×4, 5×5, and 6×6 come into view that could not exist because of the fewer layers in previous cubes.

But all other strategies and algorithms remain the same as lower-order cubes.

It is that elegance, beauty, and simplicity, the complexity, that I have come to appreciate from cubing. And the process of abstracting generalizations that apply to all (n-layer) cubes that I learned by developing strategies for solving (n-1)-, (n-2)-, and (n-3)-layer cubes, for example.

The same inductive reasoning do we strive for in qualitative research designs.

CYA: Consider Your Audience!

It is interesting that Dr. Winsten-Bartlett mentioned the Academy of Management as a potential audience. I recently completed reviewing two papers for presentation at the Academy of Management annual meeting this August in Montréal in the Business Policy & Strategy category. Both papers were highly theoretical and quantitative and nature. From reviewing these papers I gained the sense that the Academy of Management comprises highly educated members of the academic and professional community who are prepared to delve deeply into topical and compelling issues that are thoroughly grounded in theory. The Academic of Management is an example of one of organization to which the results of my proposed quantitative study assessing the performance of Islamic Shariah-compliant debt instruments could be presented. In selecting the data for presentation to the Academy of Management, I would include a comprehensive review of the literature outlining the background behind Shariah law and the potential number of customers the issue affects. I would include a balanced assessment of the results, including a sensitivity analysis to put the data into context as well as test statistics to demonstrate the validity of the findings. Presentation at the annual meeting as well as publication in one of the Academy’s peer reviewed journals would be the best avenue for presenting to this audience.

In presenting the results of the proposed study to the International Institute of Islamic Business and Finance (www.iiibf.org), the audience is already well-versed in issues such as potential market size affected. Members of the IIIBF are academics who would appreciate detailed sensitivity and statistical analyses and value comprehensiveness over visual presentation. Members would find most valuable a submission to their peer-reviewed journal that they could use as a reference and basis for their future work.

On the other hand, an organization greatly interested in the practical applications and interpreted results would be the Office of the Superintendent of Financial Institutions of Canada (http://www.osfi-bsif.gc.ca/), the regulator responsible for approving any applications for institutions to offer Islamic banking products in Canada. This organization, known for its stringent requirements that kept Canadian banks relatively safe during the credit crunch (OSFI, 2008), would be interested in knowing that the data are valid and accurate, but would comprise officials and practitioners who would appreciate a digest of the data in graphical format showing the potential impact on the financial market and market size. While statistical validation and sensitivity analyses are still important to support the conclusions, it is likely that these would be made available as appendices to the report and only graphical presentations and bottom-line conclusions would be presented. In this case, a brief Powerpoint presentation outlining only a distillation of the most important findings in graphical form as well as a concise written report with clear recommendations supplemented with comprehensive data in appendices would be the most effective means to communicate findings.

References

Office of the Superintendent of Financial Institutions (OSFI). (2008). Remarks by Superintendent Julie Dickinson. Retrieved February 17, 2010 from http://www.osfi-bsif.gc.ca/app/DocRepository/1/eng/speeches/Julie_Dickson_FSI_speech_2008_e.pdf

Evaluation Research: Motivations and Methods

Powell (2006) outline numerous goals of evaluation research, including accounting for use of limited resources, increasing visibility of organizations, and to provide feedback to staff. With these goals in mind, organizations can employ one of the three methods previously discussed in the course: quantitative, qualitative, or mixed methods.

In terms of quantitative evaluation research, while experimental or survey designs can still be used, due to the dynamic nature of an on-going programme, it can often be difficult to establish and maintain control variables, resulting in an inability to determine authoritatively sources of variation in performance. Survey methods can identify trends but are less than compelling methods for identifying causal relationships which could be much more convincing arguments to maintain or increase funding in today’s fiscal climate of frugality.

Similarly to summative research, qualitative research can provide a more holistic approach to evaluating social programmes. Powell (2006) points out that they can provide subjective views of dynamic programmes with great flexibility without being unduly intrusive to participants; however, he cautions that qualitative research, being subjective, is not able to provide objective data and results may or may not be representative or generalizable.

When considering evaluating a social programme’s effectiveness and making improvements, it would therefore seem natural that a sequential quantitative-qualitative approach might be appropriate; first, a quantitative survey design to assess performance, identify areas of potential improvement or increased efficiency, and then a qualitative portion to explore feelings and identify diverse potential solutions.

Powell, R. R. (2006). Evaluation research: An overview. Library Trends. 55(1):102-20.